Phentolamine: Medication for Blood Vessel Relaxation

Phentolamine is a medication that works by relaxing the muscles in blood vessels, leading to increased blood flow. It is sometimes used as a treatment for erectile dysfunction.

phentolamine FAQ

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What is phentolamine used for?

The primary application for phentolamine is for the control of hypertensive emergencies, most notably due to pheochromocytoma.

What are the side effects of phentolamine?

Phentolamine is available in an injectable form to be given by a healthcare professional directly into tissue of the mouth, a muscle, or a vein depending on the condition being treated or diagnosed. Common side effects of phentolamine include injection site pain, headache, and changes in heart rate. Phentolamine can also cause dizziness.

How does phentolamine work?

These drugs work by causing blood vessels to expand and allow more blood to flow through them. Phentolamine is available in an injectable form to be given by a healthcare professional directly into tissue of the mouth, a muscle, or a vein depending on the condition being treated or diagnosed.

What class is phentolamine?

This compound belongs to the class of organic compounds known as alkyldiarylamines. These are tertiary alkylarylamines having two aryl and one alkyl groups attached to the amino group. Gould L, Reddy CV: Phentolamine. Am Heart J. 1976 Sep;92 (3):397-402. doi: 10.1016/s0002-8703 (76)80121-4. [ Article]

Where can I find information about phentolamine?

You can also call Precision Dose Inc. at 1-800-397-9228 or visit www.precisiondose.com. Phentolamine package insert / prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions and pharmacology.

Is Phentolamine a pheochromocytoma inhibitor?

Phentolamine is a competitive β-adrenergic blocking agent that has direct relaxant effects on vascular smooth muscle. It is only indicated in the specific setting of acute hypertensive crises secondary to excess circulating catecholamines from a pheochromocytoma, or reactions involving a monoamine oxidase inhibitor.