Understanding Testosterone-related Medical Conditions

Explore medical conditions related to testosterone imbalance, including hypogonadism, infertility, and hormonal disorders.
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Hormonal Imbalances | Endocrine Disorders | Male Reproductive Health | Testosterone Disorders | Hormonal Imbalance Conditions | Male Hormone Health
Prepared by Nick Harper, reviewed by Dr. David James Simpson

Testosterone-related Medical Conditions FAQ


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What causes abnormal testosterone levels?

As testosterone in your blood increases, it suppresses the production of gonadotropin-releasing hormone, which helps maintain normal levels of testosterone. If any of these organs — your hypothalamus, pituitary gland or gonads — aren’t working normally, that can cause abnormal testosterone levels. What tests measure testosterone levels?

Which inflammatory diseases affect testosterone production?

Certain inflammatory diseases, such as sarcoidosis, histiocytosis and tuberculosis, involve the hypothalamus and pituitary gland and can affect testosterone production. HIV/AIDS. HIV/AIDS can cause low levels of testosterone by affecting the hypothalamus, the pituitary and the testes.

What causes low testosterone levels in men?

Low levels of testosterone, also called low T levels, can produce a variety of symptoms in men, including: While testosterone production naturally tapers off as a man ages, other factors can cause hormone levels to drop. Injury to the testicles and cancer treatments such as chemotherapy or radiation can negatively affect testosterone production.

Is testosterone a hormone?

Last reviewed by a Cleveland Clinic medical professional on 09/01/2022. Learn more about our editorial process. Testosterone is a hormone that your gonads (testicles or ovaries) mainly produce. Testosterone levels are naturally much higher in people assigned male at birth.

What is testosterone deficiency?

Testosterone is the principal androgen in men. The term ‘testosterone deficiency (TD)’ is used throughout, in preference to hypogonadism, which refers to underactivity of both endocrine and reproductive function of the testes. TD is a well-established and significant medical condition [ 1, 2 ].

What causes low testosterone?

Any issue with your testicles, hypothalamus or pituitary gland can cause low testosterone (male hypogonadism). What is a low testosterone level? The American Urology Association (AUA) considers low blood testosterone to be less than 300 nanograms per deciliter (ng/dL) for adults.

Testosterone-related Medical Conditions References

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